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                          June 9, 2023

       James McArthur, Ph.D.
       President and Chief Executive Officer
       PepGen Inc.
       321 Harrison Avenue, 8th Floor
       Boston, Massachusetts 02118

                                                        Re: PepGen Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed June 2, 2023
                                                            File No. 333-272378

       Dear James McArthur:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Alan
Campbell at 202-551-4224 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              James Xu, Esq.